Pemoline (Cyiert)

Brand Name - Cyiert, Cylert Chewable

  • Type of Drug: Psychotherapeutic.
  • Prescribed for: Children with attention deficit disorder (ADD) who are also in a program of social, psychological, and educational counseling. It may also be prescribed to treat daytime sleepiness.

Pemoline (Cyiert) General Information

This drug stimulates the central nervous system, although its exact action in children with ADD is not known. It should always be used as part of a total therapeutic program and only when prescribed by a qualified physician trained to treat ADD.

Cautions and Warnings

People who are allergic or sensitive to Pemoline should not use it. Children under age 6 should not take this medication. Psychotic children may get worse while taking it. People on this drug should have periodic liver function tests.

Possible Side Effects

  • Less common: sleeplessness, appetite loss, stomachache, rash, irritability, depression, nausea, dizziness, headache, drowsiness, and hallucinations.
  • Rare: drug hypersensitivity, wandering eye, and uncontrolled movements of the lips, face, tongue, and extremities.

Pemoline (Cyiert) Drug Interactions

• Pemoline decreases the seizure threshold and may increase the dosage requirement for anticonvulsant medications.
• Pemoline increases the effects of other nervous-system stimulants, causing nervousness, irritability, sleeplessness, and other effects.

Food Interactions

Take this medicine with food if it causes stomach upset.

Usual Dose

37.5 to 75 mg per day; not more than 112.5 mg per day.


Symptoms of overdosage are rapid heartbeat, hallucinations, agitation, uncontrolled muscle movements, and restlessness. Overdose victims must be taken to a hospital emergency room. ALWAYS bring the medicine bottle.

Pemoline (Cyiert) Special Information

Take your daily dose at the same time each morning. Taking Pemoline too late in the day can result in trouble sleeping. Call your doctor if this happens.

If you forget a dose of Pemoline, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not take a double dose.

Pemoline (Cyiert) Special Populations

This drug crosses into the fetal blood circulation. Animal studies have shown that large Pemoline doses can cause stillbirths and reduce newborn survival. When the drug is considered essential by your doctor, its potential benefits must be carefully weighed against its risks.

This drug passes into breast milk but has caused no problems among breast-fed infants. Nursing mothers who take Pemoline should watch their babies for possible drug side effects.