In transplantation, a rejection may occur, which in most cases occurs during the first weeks after surgery. With today’s effective medicines, this only happens in 20 percent of cases. In case of rejection, cortisone is first given in high doses to suppress the inflammation. The next step is to provide specific anti-T-cell drugs, e.g. ATG (antithymocytoglobulin) or OKT3, or specific B-cell agents such as Mabthera (rituximab), which are highly effective. Read full descriptions of immunosuppressive drugs in this section.