Brand Name - Aches-n-Pains, Advil

  • Type of Drug: Nonsteroidal anti-inflammatory drug (NSAID).
  • Prescribed for: Rheumatoid arthritis, osteoarthritis, mild to moderate pain, juvenile rheumatoid arthritis, sunburn treatment, menstrual pain, fever.

Ibuprofen General Information

NSAIDs are drugs that relieve pain and inflammation. We do not know exactly how they work, but part of their action may be due to an ability to inhibit the body’s ability to make a hormone called prostaglandin and inhibit the action of other body chemicals, including cyclo-oxygenase, lipoxygenase, leukotrienes, lysosomal enzymes, and a host of other factors. NSAIDs are generally absorbed into the bloodstream fairly rapidly, but some work more quickly than others. NSAIDs are generally broken down in the liver and eliminated through the kidneys. Over-the-counter doses of Ibuprofen provide pain relief but are below the level at which a significant anti-inflammatory response is usually seen. Anti-inflammatory doses are in the prescription range (400 mg per dose or more) and take a week or more to develop. Pain relief should come within 30 minutes or so of taking an over-the-counter dose.

Ibuprofen Cautions and Warnings

People who are allergic to Ibuprofen (or to any other NSAID) and those with a history of asthma attacks brought on by another NSAID, by Iodides, or by Aspirin should not take these medicines.

NSAIDs can cause gastrointestinal bleeding, ulcers, and perforation. This can occur at any time, with or without warning, in people who take chronic NSAID treatment. People with a history of active gastrointestinal bleeding should be cautious about taking any NSAID. Minor stomach upset, gas, or distress is common during the first few days of treatment with the NSAIDs. People who develop these symptoms and continue their NSAID treatment should be aware of the possibility of developing more serious drug toxicity.

NSAIDs can affect platelets and blood clotting at high doses and should be avoided by people with clotting problems and those taking Warfarin.

People with heart problems who use an NSAID may find that their arms and legs or feet become swollen.
People taking Ibuprofen, especially those with a collagen disease such as systemic lupus erythematosus, may experience an unusually severe drug sensitivity reaction. Report any unusual symptoms to your doctor at once.

NSAIDs can cause severe toxic effects to the kidney. Report any unusual side effects to your doctor, who may need to periodically test your kidney function.

NSAIDs can make you unusually sensitive to the effects of the sun (photosensitivity).

Possible Side Effects

  • Common: diarrhea, nausea, vomiting, constipation, Stomach gas, upset stomach, and stomach irritation.
  • Less common: stomach ulcers, gastrointestinal bleeding, loss of appetite, hepatitis, gallbladder attacks, painful urination, poor kidney function, kidney inflammation, blood and protein in the urine, dizziness, fainting, nervousness, depression, hallucinations, confusion, disorientation, tingling in the hands or feet, light-headedness, itching, sweating, dry nose and mouth, heart palpitations, chest pain, difficulty breathing, and muscle cramps.
  • Rare: severe allergic reactions, including closing of the throat, fever and chills, changes in liver function, jaundice, and kidney failure. These people must be treated in a hospital emergency room or doctor’s office.

Severe skin reactions have occurred while taking this medication; these should be treated promptly by a physician.

Ibuprofen Drug Interactions

• NSAIDs can increase the effects of oral anticoagulant drugs, such as Warfarin. You may take this combination, but your doctor may have to adjust your anticoagulant dose to take this effect into account.
• The blood-pressure-lowering effect of beta blockers may be reduced by NSAIDs.
• Taking an NSAID together with Cyclosporine may increase the toxic effects of each drug on the kidney.
• Ibuprofen and Indomethacin may increase Digoxin levels in the blood.
• NSAIDs may increase blood levels of Phenytoin, leading to increased Phenytoin side effects.
• Blood-Lithium levels may be increased in people taking Lithium and an NSAID.
• Methotrexate toxicity may be increased in people taking Methotrexate and an NSAID.
• NSAID blood levels may be affected by Cimetidine because of that drug’s effect on the liver.
• Probenecid may interfere with the elimination of NSAIDs from the body, increasing the chances for NSAID toxic reactions.
• Aspirin and other salicylates may decrease the amount of NSAID in your blood. These medicines should never be taken at the same time.

Food Interactions

Take this medicine with food or a magnesium/aluminum antacid if it upsets your stomach.

Usual Dose

  • Adult: 200 to 800 mg 4 times per day, depending on the condition being treated. Follow your doctor’s directions. If you are using an over-the-counter product, do not take more than 1200 mg (6 tablets) in 24: hours.
  • Mild to moderate pain: 200 mg every 4 to 6 hours.
  • Child: Juvenile arthritis: 9 to 18 mg per pound of body weight per day divided into several doses. If you are using an over-the-counter Ibuprofen product to treat a fever, the dose is 2 to 4.5 mg per pound of body weight, depending on the level of the fever, up to 4 doses a day. FOLLOW PACKAGE DIRECTIONS.


People have died from NSAID overdoses. The most common signs of overdose are drowsiness, nausea, vomiting, diarrhea, abdominal pain, rapid breathing, rapid heartbeat, sweating, ringing or buzzing in the ears, confusion, disorientation, stupor, and coma. Take the victim to a hospital emergency room at once for treatment. ALWAYS bring the medicine bottle with you.

Ibuprofen Special Information

  • Ibuprofen can make you drowsy and/or tired: Be careful when driving or operating equipment.
  • Do not take any nonprescription products with Acetaminophen or Aspirin while taking any NSAID.
  • Avoid alcoholic beverages while taking an NSAID.
  • Take each dose with a full glass of water, and don’t lie down for 15 to 30 minutes after you take the medicine.

Contact your doctor if you develop skin rash, itching, visual disturbances, weight gain, breathing difficulty, fluid retention, hallucinations, black stools, persistent headache, or any unusual side effects, or if side effects become intolerable.

If you forget to take a dose of Ibuprofen, take it as soon as you remember. If you take several Ibuprofen doses a day and it is within 4 hours of your next regularly scheduled dose, skip the one you forgot and continue with your regular schedule. Do not take a double dose.

Special Populations

NSAIDs may cross into the blood circulation of a developing fetus. They have not been found to cause birth defects, but animal studies have indicated a possible effect on the developing fetal heart if taken during the last half of pregnancy. Pregnant women or those who might become pregnant while taking Ibuprofen should not take it without their doctor’s approval. When the drug is considered essential by your doctor, the potential risk of taking the medicine must be carefully weighed against the benefit it might produce.

NSAIDs may pass into breast milk but have caused no problems among breast-fed infants, except for seizures in a baby whose mother was taking Indomethacin. Other NSAIDs have caused problems in animal studies. There is a possibility that a nursing mother taking an NSAID could affect her baby’s heart or cardiovascular system. If you must take Ibuprofen, use an alternative feeding method.

Older adults, especially those with poor kidney or liver function, may be more susceptible to the side effects of the NSAIDs.